Health depends on communication. Every cell must receive, interpret, and respond to signals to function properly. When cellular communication is clear, key systems like immunity, digestion, and cognition work in harmony.* Ambrotose® delivers patented multiglycan technology, powered by Manapol®, to support that communication.*
Every cell must receive, interpret, and respond to signals to function properly. When cellular communication is clear, key systems like immunity, digestion, and cognition work in harmony.* When that signal is disrupted, the body's efficiency and adaptability decline.
Aging, stress, nutrient gaps, gut imbalance, and environmental stressors can all interfere with cell signaling, making it harder for the body to maintain health.*
Developed by Mannatech, backed by scientific studies and providing 30+ years of powerful health results, Ambrotose® features premium glycans from plant sources.* Manapol®, arabinogalactan, tragacanth and the other unique Ambrotose ingredients contain high-molecular-weight glycans with unique structures and sugar profiles.
Aging, stress, nutrient gaps, gut imbalance and environmental stressors all interfere with how clearly your cells communicate.*
Manapol® aloe vera extract, featured in Ambrotose, contains the highest concentration of bioactive glycans (polysaccharides) in aloe: acemannan.* Available in powders, capsules, and a flavored drink mix.
A premium aloe vera extract from Costa Rica, processed to stay remarkably close to fresh aloe and rich in the bioactive glycan that matters most: acemannan.*
Think all aloe is the same? Here are three tested, proven factors to weigh when comparing aloe. We included fresh aloe so you can see how Manapol's premium processing yields an extract far closer to fresh aloe than the competitor's.
% total polysaccharides by aloe source. Manapol® delivers more than double the competitor, and edges out fresh aloe itself.
Acemannan consists of high-molecular-weight polysaccharides, around 1–2 million Daltons, that are more likely to reach the lower digestive tract, where they can help support beneficial gut microbial activity.*
The competitor's extract is 85.8% very-small polysaccharides with less than 1% acemannan. Manapol® keeps the broad, fresh-aloe-like spectrum, with 43% true acemannan.
1–2M Daltons · reaches the lower gut*After experiencing the power of glycans in aloe, Ambrotose was created to include a blend of glycans for a greater variety of unique glycan structures and sugar profiles, to further increase potential health benefits.*
Manapol® leads, and these plant-sourced glycans round out the formula's variety of structures and sugar profiles.*

A plant-based polysaccharide sourced from larch trees. The glycans are large, and the sugar profile is predominantly galactose and arabinose. These unique glycans support the immune system and help nourish beneficial gut bacteria, including bifidobacteria and L. plantarum.*

A natural fiber derived from the dried sap of the Astragalus gummifer plant. Its polysaccharides are large, built from galacturonic acid, arabinose, xylose, galactose, and fucose. It functions as a prebiotic fiber, supporting immune health and helping maintain healthy cell-to-cell communication.

A plant-sourced amino sugar used by the body as a building block for key saccharides. These saccharides support cellular structure, communication, and immune function.*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
** Improvements observed within 8 weeks in a scientific study of the Ambrotose formulation. The well-being chart above is a directional illustration of study trends, not a plot of published data.
† Historically, more than 65 patents have been issued in major global markets for the technology related to the Ambrotose formulation. Mannatech currently holds 17 patents in major global markets related to the Ambrotose technology.
Pricing, ratings, and review excerpts reflect usa.mannatech.com at the time this page was prepared.