The original.
The only.
The best.

Health depends on communication. Every cell must receive, interpret, and respond to signals to function properly. When cellular communication is clear, key systems like immunity, digestion, and cognition work in harmony.* Ambrotose® delivers patented multiglycan technology, powered by Manapol®, to support that communication.*

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Plant-sourced glycans Powders · Capsules · Drink mix 100% True Acemannan
Ambrotose® Complex Powder, Glyconutritional Dietary Supplement
Featured Extract
Manapol®
Bioactive Glycans
Acemannan
30+
Years
Of powerful health results*
65
Patents†
Issued historically in major global markets
9
Clinical Studies
On the Ambrotose® formulation
100%
True Acemannan
Guaranteed in every batch

Health depends on
communication.

Every cell must receive, interpret, and respond to signals to function properly. When cellular communication is clear, key systems like immunity, digestion, and cognition work in harmony.* When that signal is disrupted, the body's efficiency and adaptability decline.

Aging, stress, nutrient gaps, gut imbalance, and environmental stressors can all interfere with cell signaling, making it harder for the body to maintain health.*

Developed by Mannatech, backed by scientific studies and providing 30+ years of powerful health results, Ambrotose® features premium glycans from plant sources.* Manapol®, arabinogalactan, tragacanth and the other unique Ambrotose ingredients contain high-molecular-weight glycans with unique structures and sugar profiles.

Modern life disrupts the signal.

Aging, stress, nutrient gaps, gut imbalance and environmental stressors all interfere with how clearly your cells communicate.*

The answer is Manapol®.

Manapol® aloe vera extract, featured in Ambrotose, contains the highest concentration of bioactive glycans (polysaccharides) in aloe: acemannan.* Available in powders, capsules, and a flavored drink mix.

Manapol® powers every
Ambrotose® formula

A premium aloe vera extract from Costa Rica, processed to stay remarkably close to fresh aloe and rich in the bioactive glycan that matters most: acemannan.*

Foundational support, from a single plant

  • Foundational health to support your cells*
  • Supports healthy microbiome balance*
  • Supports blood sugar levels already in the normal range*
  • Supports healthy immune system function*
  • Helps support proper digestive system function*
Manapol® Immune Support Formula, glyconutritional dietary supplement, 1.05 oz / 30 g
Manapol® · True Acemannan
Asset Drop Zone
Podcast · Landen × Tait × Dr. Nugent
Embed the Manapol conversation here if the recording is available (audio player or video embed).

Discover the Manapol difference*

Think all aloe is the same? Here are three tested, proven factors to weigh when comparing aloe. We included fresh aloe so you can see how Manapol's premium processing yields an extract far closer to fresh aloe than the competitor's.

01
High percentage of total polysaccharides
Polysaccharides are the active components of aloe vera, attributable to the many health benefits associated with the gel of the aloe leaf.*
Manapol® Costa Rica
67%
Fresh Aloe
63%
Competitor Aloe China & Mexico
32.9%

% total polysaccharides by aloe source. Manapol® delivers more than double the competitor, and edges out fresh aloe itself.

02
Size and diversity of size both matter
A natural blend of low-, medium-, and high-molecular-weight polysaccharides. At least 43% meet the official definition of acemannan.
43% ACEMANNAN
Manapol® Powder
Broad, fresh-aloe-like spectrum
80% ACEMANNAN
Fresh Aloe
The natural benchmark
<1% ACEMANNAN
Competitor Aloe
China & Mexico · 85.8% very small
Very large (Acemannan) Medium Small / very small

Larger molecules reach the lower gut.

Acemannan consists of high-molecular-weight polysaccharides, around 1–2 million Daltons, that are more likely to reach the lower digestive tract, where they can help support beneficial gut microbial activity.*

The competitor's extract is 85.8% very-small polysaccharides with less than 1% acemannan. Manapol® keeps the broad, fresh-aloe-like spectrum, with 43% true acemannan.

1–2M Daltons · reaches the lower gut*
03
Sugar profile comparison
A diverse glycan profile led by mannose rather than glucose, aligned with modern dietary guidance to limit unnecessary glucose intake.
Sugar TypeManapol® PowderCompetitor AloeFresh Aloe
Mannose (key aloe sugar)64.7%53.8%65.2%
Glucose (simple sugar)7.1%43.2%15.9%
Galactose (milk sugar)3.1%4.9%11%
Other unique aloe sugars6 detectedNot detected6 detected
Manapol® is mannose-led (64.7%) and supported by galactose, arabinose, rhamnose, fucose, xylose and uronic acids. Galacturonic acid (13.8%) signals the presence of aloe pectin, a dietary fiber that supports digestive health, immune function, and overall wellness.* The leading competitor's aloe is glucose-dominant (43.2%) and lacks six of the unique sugars found in Manapol. Manapol contains just 7.1% glucose.

It started with aloe.
It became something more.

After experiencing the power of glycans in aloe, Ambrotose was created to include a blend of glycans for a greater variety of unique glycan structures and sugar profiles, to further increase potential health benefits.*

Improvements observed within 8 weeks in a scientific study help support:**

OutcomeResult
Memory*↑ Improved
Immune Health*↑ Improved
Overall Wellbeing*↑ Improved
Mood & Irritability*↑ Improved
Recall*↑ Improved
Digestive Function*↑ Improved
Psychological General Well-Being Index (PGWBI), 8-week trend
Directional illustration of well-being trends observed over an 8-week study period. Higher is better.
90 85 80 75 Baseline Week 4 Week 8 Ambrotose® Placebo

Additional key ingredients

Manapol® leads, and these plant-sourced glycans round out the formula's variety of structures and sugar profiles.*

Arabinogalactan, a polysaccharide sourced from larch trees

ARABINOGALACTAN

A plant-based polysaccharide sourced from larch trees. The glycans are large, and the sugar profile is predominantly galactose and arabinose. These unique glycans support the immune system and help nourish beneficial gut bacteria, including bifidobacteria and L. plantarum.*

Gum tragacanth, a natural fiber from the Astragalus gummifer plant

GUM TRAGACANTH

A natural fiber derived from the dried sap of the Astragalus gummifer plant. Its polysaccharides are large, built from galacturonic acid, arabinose, xylose, galactose, and fucose. It functions as a prebiotic fiber, supporting immune health and helping maintain healthy cell-to-cell communication.

Glucosamine HCl, a plant-sourced amino sugar

GLUCOSAMINE HCl

A plant-sourced amino sugar used by the body as a building block for key saccharides. These saccharides support cellular structure, communication, and immune function.*

Trusted for more than 30 years.

Ambrotose® Complex Powder jar
★★★★★
"I've been using Ambrotose Complex for 30+ years, since the day it became available. I don't go a day without my 2 scoops! I feel it has kept me well and energized all these years."
Judith D. · US · 07/25/25 · Ambrotose Complex powder
Verified Buyer
★★★★★
"We truly value its wide-ranging health benefits and appreciate the bundle savings and loyalty points…"
Steve L. · Ambrotose Complex powder
Verified Review
Ambrotose® Complex Powder
Ambrotose® Complex Powder · 3.5 oz / 100 g

Add the original glyconutrient to your daily routine.

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Mission 5 Million® · With each purchase, 150 servings of PhytoBlend™ powder go to a child in need.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

** Improvements observed within 8 weeks in a scientific study of the Ambrotose formulation. The well-being chart above is a directional illustration of study trends, not a plot of published data.

† Historically, more than 65 patents have been issued in major global markets for the technology related to the Ambrotose formulation. Mannatech currently holds 17 patents in major global markets related to the Ambrotose technology.

Pricing, ratings, and review excerpts reflect usa.mannatech.com at the time this page was prepared.